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Scientists find the gene that drives T-cell exhaustion, revealing new strategy to improve immune responses

Immunotherapy, which uses a patient’s immune system to treat disease, has increased survival for some adults and children with cancer. However, it has had limited success against many pediatric solid tumors, in part because T cells can become functionally impaired or “exhausted.” St. Jude Children’s Research Hospital scientists published results in Nature showing that the gene ZMYND8 is a major regulator of CD8+ T-cell exhaustion.

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Breath tests could distinguish cancerous lung nodules from benign ones

Human breath could help identify cancerous lung nodules and reduce the need for invasive testing. New Griffith University research analyzed exhaled breath to help doctors distinguish between cancerous and noncancerous lung nodules, supporting earlier lung cancer diagnosis. Approximately 2.5 million new cases of lung cancer are diagnosed each year.

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Smart contact lens detects serotonin changes in tear samples collected during stress test

A research team led by Dr. Yangzhi Zhu, principal investigator and assistant professor at the Terasaki Institute for Biomedical Innovation, has developed a soft, reusable smart contact lens as part of its broader Ocular Library for the Analysis of Tear Biomarkers (OCULAB), a tear bioelectronics platform for noninvasive, longitudinal biochemical monitoring through the ocular surface and tear film.

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