A scientist at Cincinnati Children’s who has hunted for decades for ways to shrink the painful and disfiguring nerve tumors caused by neurofibromatosis type 1 (NF1) has made a new breakthrough in the quest.
Where and how does an Alzheimer’s tangle begin? A new study by neuroscientists at Columbia University challenges a long-held assumption about the source of toxic tau proteins, which form neurofibrillary tangles and are closely linked to memory decline in Alzheimer’s disease.
Liver cancer is difficult to treat because tumors vary greatly from patient to patient. Researchers at the University of Basel have captured this diversity by creating a collection of mini-tumors, which they use to systematically search for new treatment options. They tested more than 1,600 compounds using these organoids and used the results to develop promising drug combinations.
Lab-grown tissues engineered from stem cells reprogrammed from human cells, called human induced pluripotent stem cells (hiPSCs), are rapidly emerging as a more reliable and accessible model in medical research.
A QIMR Berghofer-led team has developed a powerful tool to explore and understand the mysterious workings of the vast region of the human genome once dismissed as “junk DNA,” discovering thousands of molecules that could hold the key to new precision cancer treatments.
Data from more than 17,000 people linked higher blood levels of xylitol to an increased risk of death, heart attack, and stroke over the long term.
From a standard blood draw, a clinical lab isolates peripheral blood mononuclear cells (PBMCs), which are predominantly immune cells, and then counts the abundance of different cell types, along with some basic measures of how they’re functioning.
Researchers developed a method for placing microscopic sensor particles within the printed material itself, allowing researchers to measure nutrient levels—and infer cell health from this information—using only light.
Researchers from the Atopy (Allergy) Research Center of the Juntendo University Graduate School of Medicine in Japan, led by Prof. François Niyonsaba, along with co-authors Quan Sun and Ge Peng, explored the relationship between melanoma cells and keratinocytes, the most abundant cells in the skin that surround melanoma cells.
Researchers have evaluated a novel smart wheeled walker designed to enhance mobility and safety for aging populations. Published in JMIR Aging, the randomized crossover trial revealed that the smart wheeled walker significantly improved walking speed, reduced exertion and boosted dynamic balance compared with a traditional 4-wheeled rollator.