
Capturing the complete process of embryonic development
By tracking over 1 million cells, researchers created a detailed map of embryonic development in mice. It could provide development and disease insights.

By tracking over 1 million cells, researchers created a detailed map of embryonic development in mice. It could provide development and disease insights.

One person dies every 50 seconds in the U.S. from cancer, and an estimated 39% of people in the country will develop cancer during their lifetime. Survival rates have improved in recent decades from innovations and combinations of treatments, including surgery, chemotherapy, radiation, immunotherapy and biotechnology. Still, some cancers resist treatment or recur.

Researchers affiliated with the Leibniz Institute of Polymer Research Dresden (IPF) and the Else Kröner Fresenius Center (EKFZ) for Digital Health at TU Dresden have developed a 3D-printed implant prototype that combines the recording of brain activity with targeted cooling. The technology could pave the way for alternative approaches to treating drug-resistant focal epilepsy. The research is published in the journal Advanced Science.

Researchers at Baylor College of Medicine have discovered a new strategy that glioblastoma, the most common and aggressive form of adult brain cancer, uses to fuel its own growth. Published in the journal Neuron, the study shows in animal models that glioblastoma hijacks the activity of neighboring brain cells, flipping them from a role that limits tumor growth to one that promotes it. The findings point to new treatment possibilities for this deadly cancer, which has seen only minimal gains in patient survival over the past half century.

Reliably recording brain activity over many hours has so far been fraught with technical and practical challenges. While traditional electroencephalography (EEG) systems provide meaningful data, they are often uncomfortable and typically limited to controlled testing environments. Is it even possible to record EEG signals with good signal quality in everyday situations?

This targeted approach could offer a way to prevent the recurrence of aggressive brain tumors.

Our sense of smell is crucial to perceiving the world around us; it’s linked to memories and can even affect emotions. However, our sense of smell remains one of the last frontiers to be digitally recreated. Unlike vision and sound, which can now be easily reproduced by all types of devices in our homes, smell cannot yet be digitally reproduced to let us experience the delicious casserole from a cooking show or the musky forest floor from a nature documentary.

Scientists at Trinity College Dublin have made a breakthrough in understanding how cancer cells can evade the cell-killing effects of chemotherapy and enter a “zombie-like state,” called premature senescence, that can attract the wound-healing properties of the immune system.

What if we could use a cancer’s own byproduct to make drugs that destroy tumor cells from the inside? That is what Katsunori Tanaka and his team have done at the RIKEN Pioneering Research Institute (PRI) in Japan.

In a world-first international trial, adding intismeran, a type of personalized therapeutic cancer vaccine made from each patient’s own tumor, to pembrolizumab immunotherapy after surgery for high-risk melanoma reduced the risk of recurrence or death by 42%.