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Immune ‘fingerprints’ aid diagnosis of complex diseases

Your immune system harbors a lifetime’s worth of information about threats it’s encountered—a biological Rolodex of baddies. Often the perpetrators are viruses and bacteria you’ve conquered; others are undercover agents like vaccines given to trigger protective immune responses or even red herrings in the form of healthy tissue caught in immunological crossfire.

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Scientists discover a new mechanism for how glioblastoma reprograms tumor-infiltrating neutrophils

The lab of Filippo Veglia, Ph.D., at The Wistar Institute has discovered a previously unknown mechanism for how aggressive brain cancers reprogram immune system cells from fighting cancer to enabling further tumor growth. The team’s findings were published in the paper “Functional reprogramming of neutrophils within the brain tumor microenvironment by hypoxia-driven histone lactylation,” from Cancer Discovery.

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