Personalized vaccine targets melanoma recurrence

A personalized cancer vaccine could help prevent melanoma from returning after surgery. Sutter investigators Dr. Kevin Kim, oncologist and chief of precision medicine at Sutter Health, and Dr. Mohammed Kashani-Sabet, medical director of Sutter CPMC's Cancer Center, led Sutter's participation in the phase 2 KEYNOTE-942 study that helped make possible this advance.

Sutter Health investigators helped contribute to the earlier phase 2 research that established promising evidence for this personalized vaccine approach. Now, newly released results from the larger international phase 3 INTerpath-001 trial provide further evidence of its potential, showing that the personalized mRNA vaccine combined with pembrolizumab reduced the risk of melanoma recurrence or death at two years compared with pembrolizumab alone.

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