Smart contact lens detects serotonin changes in tear samples collected during stress test

A research team led by Dr. Yangzhi Zhu, principal investigator and assistant professor at the Terasaki Institute for Biomedical Innovation, has developed a soft, reusable smart contact lens as part of its broader Ocular Library for the Analysis of Tear Biomarkers (OCULAB), a tear bioelectronics platform for noninvasive, longitudinal biochemical monitoring through the ocular surface and tear film.

Stress affects many aspects of physical and mental health, yet physiological changes associated with stress can be difficult to monitor objectively over time. Serotonin is an important signaling molecule involved in mood regulation and stress-related physiology. It is also present in tears, making tear fluid an attractive, minimally invasive source of biochemical information. The study was designed to explore whether a soft ocular bioelectronic platform could sensitively detect serotonin in this small and dynamic biofluid.

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