Chemotherapy faces a fundamental problem: The same drugs powerful enough to kill cancer cells can also damage healthy tissue.

Patients with relapsed or refractory multiple myeloma often run out of effective treatment options after multiple rounds of therapy.

Mount Sinai researchers have identified how APOE4, the strongest genetic risk factor for Alzheimer’s disease, damages the brain’s blood vessels and promotes the buildup of abnormal proteins linked to neurodegenerative disease.