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New technique involving metal carbonyl allows researchers to track chemotherapy drugs inside cells

Scientists have made significant progress in developing cancer therapies that help patients across cancer types. However, they face limitations in determining the results of drug effectiveness, as well as ensuring even distribution among all cancer cells because of the highly compact nature of tumors. Researchers are working to change that by giving chemotherapy drugs a kind of chemical “signal” that allows them to be tracked inside of cells.

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Researchers find a new targeted approach to shut down prostate cancer growth

Prostate cancer relies on genetic “switches,” called enhancers, that can turn on tumor-promoting genes. Researchers at the University of Michigan Health Rogel Cancer Center have discovered histone H2B N-terminal acetylation (H2BNTac), an essential chemical mark of these enhancers. They further implicate two proteins, p300 and CBP, that add these marks, and along with the androgen receptor, turn on enhancers and promote prostate cancer growth.

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