MedTech News:

DISEASE ADVANCES

Cancer-promoting proteins may make tumors easier to spot… but also help them evade immune attack

The immune system may recognize a cancer cell and still fail to destroy it. In a recent study, researchers at Hiroshima University and their international collaborators found that hyperactive YAP and TAZ (YAP/TAZ), two cancer-promoting proteins, were associated with genomic instability that may make cancer cells more recognizable to the immune system, while also increasing PD-L2, which helps the cells suppress T-cell attack.

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Blood test offers new way to track lung cancer

Northwestern Medicine scientists and collaborators have demonstrated a novel liquid biopsy technique that can measure cancer burden and reveal molecular characteristics of small cell lung cancer (SCLC), according to a new study published in the Journal of Clinical Investigation.

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Immune system protein is a cancer killer on its own, new study shows

For decades, scientists have known that a protein made by T cells and natural killer (NK) cells in the immune system, called perforin, can kill tumor cells by punching a hole in the cell wall and injecting proteases called granzymes, which kill the cell. Now, new work led by researchers at the University of Michigan Health Rogel Cancer Center found that tumor cells could be killed even when major granzymes were missing.

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