A research team has made a breakthrough in epigenetic drug discovery. The researchers have successfully developed a first-in-class chemical inhibitor that precisely and selectively targets the ATAC complex, a critical cellular “switch operator” that activates tumor-promoting genes, opening a novel therapeutic avenue for non-small cell lung cancer (NSCLC).

A Europe-wide study led by the University Medical Center Göttingen (UMG) shows that the microbial composition of the gut, known as the gut microbiome, can predict long-term complications following severe acute pancreatitis.

A simple blood test can help detect cancer in patients with non-specific symptoms such as fatigue, pain or weight loss. This is according to a Swedish study from Karolinska Institutet, Danderyd Hospital and others, published in Nature Communications.

Steatotic liver disease (commonly called fatty liver disease) progresses silently. Even in the absence of noticeable symptoms, changes begin to unfold inside the liver.

An estimated 3 million Americans have an inflammatory bowel disease (IBD) such as Crohn’s disease or ulcerative colitis. But a lucky few individuals are far less likely to develop IBD because they have a rare variant of a gene called CARD9. This protective gene variant prevents the long-term digestive tract inflammation that can cause tissue damage and lead to disease.

Coffee may do more than boost energy. New research suggests that certain compounds found in roasted coffee beans could help slow how quickly sugar enters the bloodstream, a finding that could one day support new foods aimed at managing type 2 diabetes.

Researchers at Mass General Brigham and Karolinska Institutet have identified a new method to predict asthma exacerbations with a high degree of accuracy.