Blog

- Andrew Celentano

Two protective genetic pathways may converge to reduce Alzheimer’s disease risk

Alzheimer’s disease is the most common form of dementia worldwide. Although the APOE ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease, not all carriers develop dementia, indicating that other genetic factors can modify disease risk. In recent years, PLCG2 has emerged as one of the most important protective genes associated with Alzheimer’s disease.

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Restoring brain immune balance opens new avenue for Alzheimer’s treatment

Professor Minah Suh of the Department of Biomedical Engineering at Sungkyunkwan University, in collaboration with the biotechnology company IMNEWRUN and Professor Ho-Keun Kwon’s team at Yonsei University College of Medicine, has identified a mechanism by which modulating an immune protein in the brain can restore a disrupted brain immune environment and reduce abnormally elevated neuronal activity in an animal model of Alzheimer’s disease.

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