Ischemic stroke can leave lasting neurological damage after the initial vascular event, with oxidative stress, neuroinflammation, neuronal death and disruption of neural connectivity contributing to impaired recovery. Although current interventions provide partial protection, their ability to prevent delayed neuronal injury remains limited, highlighting a major barrier to functional recovery.

University of Manchester–led researchers have unveiled a roadmap for making computer-generated evidence trustworthy enough to help regulators decide whether medical devices are safe and effective, alongside laboratory and clinical evidence.