MedTech News
.................... by Andrew Celentano
One dose of protein-targeting CAR-T cells shrinks solid tumors in preclinical tests
CAR-T cell therapies have fundamentally transformed the treatment of several blood and lymph node cancers.
Two studies link elevated ear protein levels in blood to tinnitus
When Dr. Kourosh Parham conceived a first-of-its-kind blood test for tinnitus, he knew further research was needed to confirm a link between a unique ear protein and the common hearing disorder. To validate his theory, the professor of surgery at UConn Health (UCH), Division of Otolaryngology-Head & Neck Surgery, teamed up with fellow UCH physician-scientists to conduct two clinical trials.
FDA grants 510(k) clearance for Urolution Medical’s OpenFlo catheter
Urolution Medical is preparing comparative clinical trials to evaluate catheter performance and patient outcomes.
Experiments reveal how DNA-packaging protein mutation promotes breast cancer spread
A research team led by professor Chan Kui-ming from the Department of Biomedical Sciences at CityUHK discovered that H2BE113K, a missense H2B mutation, promotes colony formation and lung metastasis in breast cancer.
Drug combination that reduces oxygen levels in tissues improves Parkinson’s symptoms in mice
In a new study, Broad Institute researchers report that two small-molecule chemicals that reduce oxygen delivery to cells improved symptoms of neurodegeneration in a mouse model of Parkinson’s disease.
Stem cell–like tumor state may help identify high-risk small-cell lung cancer
Northwestern Medicine scientists have identified a stem-like state in small-cell lung cancer that distinguishes a group of patients with exceptionally poor outcomes following chemoimmunotherapy, according to a study published in Cell Reports Medicine.
The shape of water at a key tau hotspot helps drive dementia-linked clumping
Diseases such as Alzheimer’s and frontotemporal dementia are considered neurodegenerative tauopathies, in which tau proteins in the brain misfold and lead to cognitive decline. Until now, it has been unclear how misfolded tau recruits other seemingly healthy tau and causes it to misfold and clump.
Tiny robots speed medicine through body to the heart
Johns Hopkins University engineers have created robots the size of a pencil tip intended to travel through the body to deliver medicine to infections inside a beating heart.