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- NOVEL DISCOVERIES

New AI tool predicts whether aggressive small cell lung cancer will respond to treatment

Results of a new study conclude that a pathology tool powered by artificial intelligence can predict whether a patient with extensive-stage small cell lung cancer will respond to platinum-based chemotherapy—before treatment has begun, and without additional biopsies. That means patients can avoid treatments that are unlikely to help them, have a chance to enroll earlier in clinical trials of newer drugs, and may get a clearer picture of their prognosis.

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Stress tested, testing stress: Novel organoid models how the adrenal gland develops

Sitting above each kidney are two small endocrine glands about the size of walnuts. These are the adrenal glands, responsible for producing hormones that help control some of the body’s most critical functions. Among these hormones, cortisol is particularly critical for survival. Often referred to as the “stress hormone,” it helps the body adapt to a wide range of challenges—both emotional and physical, such as trauma or infection—by regulating overall metabolism. Despite its central role in stress and endocrine biology, how the adrenal gland is built and how it functions remains poorly understood.

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Smart sensor decodes fatigue and stress from body signals on the move

About one in three employees in Singapore report feeling burnt out—one of the highest rates globally. Burnout and chronic fatigue carry a substantial economic cost and pose serious risks in professions where alertness is critical. Yet diagnosing fatigue and related mental health conditions today relies largely on self-reported questionnaires, which tend to be subjective, intermittent, and poorly suited to real-time evaluation.

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