The immune system possesses legions of T cells that, if primed, could hunt down and destroy tumors. Now, a UC San Francisco team has invented a way to do this by combining immune cells grown in the lab with samples from a patient’s tumor. Like giving a scent to a hound dog, it shows the immune system how to go after the cancer.
Inspired by the work of the RNA Therapeutics Institute at UMass Chan Medical School and the development of the COVID vaccine, Marcus Ruscetti, Ph.D., and Chaitanya Naimesh Parikh, Ph.D. ’26, have developed an immunotherapy using a cocktail of messenger RNAs (mRNA) that could potentially transform pancreatic cancer treatment.
The research highlights the role of TEX264, a protein that helps cancer cells remove and degrade PARP1 trapped on DNA following treatment
A new Northwestern Medicine study has identified a previously unknown mechanism by which an enzyme promotes cancer cell proliferation, establishing it as a promising therapeutic target for cancer, according to findings published in Nature Communications.
Researchers at Georgia State University have identified a previously unknown aspect of schizophrenia that offers a new way to understand how the disorder affects large-scale brain coordination. In a new study, published in the journal Translational Psychiatry, researchers introduced a method for measuring how brain networks maintain balanced activity and recover when that balance is disrupted.
For people living with diabetes, managing blood sugar can mean constantly watching the clock, keeping meals and medications on schedule and staying alert to changes in glucose levels. While little can be done about timed meals, researchers have developed a biological system that detects rising blood sugar levels and automatically responds by releasing medication to bring glucose back down.
Researchers from the University of California San Diego and collaborators have identified a previously overlooked pattern of DNA mutations in colorectal cancer. Scientists use these patterns, known as mutational signatures, to investigate the biological and environmental processes that have damaged DNA during cancer development.
For more than three decades, scientists have sought to combat diseases caused by protein misfolding by targeting the large protein clumps that accumulate in affected tissues. Yet, despite intensive efforts, clinical success has been limited.
Deep brain stimulation, or DBS, may help improve speech and swallowing problems caused by traumatic brain injury (TBI), according to a new University of Pittsburgh School of Medicine study published in Nature Communications.
Biomedical scientists have developed a new nanoscale imaging technique that allows researchers to directly see how bone-forming cells use nutrients and build bone inside the body.