About one in three employees in Singapore report feeling burnt out—one of the highest rates globally. Burnout and chronic fatigue carry a substantial economic cost and pose serious risks in professions where alertness is critical. Yet diagnosing fatigue and related mental health conditions today relies largely on self-reported questionnaires, which tend to be subjective, intermittent, and poorly suited to real-time evaluation.

For patients with heart failure, blood pumps can be lifesaving. But the very forces that sustain circulation can also harm it, damaging red blood cells through hemolysis and compromising the body’s oxygen supply. Now, supercomputer simulations are revealing how red blood cells deform under stress, offering new insights that could lead to safer, more effective blood pump designs.

Neuroscientists at University of Iowa Health Care have demonstrated for the first time that noninvasive brain stimulation can alter the activity of a critical deep brain region involved in emotion and memory. Moreover, the study shows that personalizing the stimulation site using a patient’s unique brain connectivity pathway can increase the neuromodulation effect.