An international research team led by Dr. Lucia Torres Fernández from the working groups of Professor Dr. Julie George and Professor Dr. Roman Thomas at the University of Cologne has identified a critical dependency in small cell lung cancer (SCLC) that can be exploited therapeutically.

A team of UTHealth Houston researchers slowed and even reversed diabetic nerve damage in mice, bringing researchers one step closer to developing a treatment for humans. The research is published in Science Translational Medicine.

A University of Minnesota–led multi-institutional research team has discovered a highly potent small molecule that blocks Ebola virus entry by stabilizing the virus’s entry protein and provides strong protection when given orally in a preclinical model.

A nasal spray containing vesicles naturally released by cells may work against Alzheimer’s. This is the promise of a study conducted by researchers at the Università Cattolica, Fondazione Policlinico Universitario A. Gemelli IRCCS, and the E. Menni Research Center of Fondazione Poliambulanza.

The brain is a black box of densely packed neurons, blood vessels and immune cells, all locked away in a sealed skull. WashU’s Song Hu has dedicated his career to unlocking that puzzle box by developing new ways to “see” inside. His team’s newest innovation could give researchers a new view of how brain cells and blood vessels work together and what happens when the coupling between the two breaks down.

A multi-institutional research team led by Georgia State University Regents’ Professor Emerita of Biochemistry and Biophysical Chemistry Jenny J. Yang has developed a new class of protein-based MRI contrast agents that detect invasive lung cancer and metastatic disease at earlier stages than conventional imaging approaches.

Immune cells can become exhausted after prolonged exposure to cancer, gradually losing their ability to attack tumor cells. This phenomenon is particularly pronounced in aggressive brain tumors and can severely limit the effectiveness of immunotherapy.

A team from the Research Institute of the McGill University Health Center (The Institute) have created a three-dimensional, beating heart-on-a-chip, or “mini-heart,” using blood cells from a patient with dilated cardiomyopathy (DCM), a leading cause of heart transplantation.

T-cell receptor, or TCR, therapy is a cancer treatment that genetically reprograms immune cells, called T cells, to hunt down cancer with precision. It’s similar to another treatment, CAR T-cell therapy, but with one key difference: CAR T-cell therapy can only spot proteins that naturally appear outside a cancer cell. TCR therapy, however, can also catch small protein fragments from inside the cell that are carried to the surface and displayed like little name tags.