A team has identified an experimental molecule capable of “reprogramming” the brain’s immune cells to restore part of their protective function against Alzheimer’s disease. The study, published in the journal Cell Death and Disease, shows that the compound, called OLE, helps microglia enclose and contain beta-amyloid plaques, reducing their size and toxicity.
Oculogica announced earlier this month that it won FDA 510(k) clearance for the SNAP concussion test.
Often called “the window to the soul,” the eyes may also offer clues about something less poetic but just as important: the health of the brain. A new study of tens of thousands of patients has revealed that cheap, simple and common photographs of the retina at the back of the eye can accurately predict many of the most common risk factors associated with developing Alzheimer’s disease.
Embolization of abnormal blood vessels using rapidly resorbable gelatin-based microspheres is safe and provides significant, lasting pain relief and functional improvement for patients with osteoarthritis-related knee pain, according to a new study published in Radiology.
Researchers at MUSC Hollings Cancer Center, led by Noel Warfel, Ph.D. revealed a previously unknown mechanism that helps prostate cancer cells evade treatment and points to a potential strategy for overcoming that resistance.
Researchers at the University of Cologne’s Center for Molecular Medicine Cologne (CMMC) have discovered a previously unknown mechanism that makes most pancreatic cancer cells susceptible to a form of programmed cell death.
A study led by Georgia Institute of Technology’s Associate Professor Costas Arvanitis takes a major step toward safer and more effective treatment and diagnosis of brain diseases. His team’s research, published in Advanced Science, shows how combining artificial intelligence (AI) with focused ultrasound can safely deliver therapies and improve diagnostic interventions to the brain.
Now, scientists at the La Jolla Institute for Immunology in California report that a live-attenuated flu vaccine administered as a nasal spray may establish a durable local immune memory in the respiratory tract, potentially strengthening defenses where the infection starts.
Tumor cells can lapse into a sleep-like state and thereby evade the destructive effect of cancer drugs. In some types of the disease, such as certain forms of lung cancer, this state is triggered by stress hormones in the body. Inside the cancer cells, glucocorticoid receptors recognize the hormones, and the cells respond by lapsing into a state in which they undergo barely any division. This renders many treatments ineffective.
Scientists are attempting to switch off these receptors with a view to waking the cancer cells up from sleep—making them vulnerable to attack.
Prostate-targeted, engineered nanoparticles made of amorphous silica are effective in killing prostate tumors directly while enhancing antitumor immunity, according to a preclinical study led by investigators at Weill Cornell Medicine and the Cornell Duffield College of Engineering.